Abstract | BACKGROUND: METHODS: Sixteen healthy volunteers without gastrointestinal disease and normal faecal calprotectin baseline values ingested their own blood twice, either by drinking or via nasogastric tube. Quantities of 100 ml and 300 ml blood were ingested in a randomised order, with a 28-day wash-out period. Faecal calprotectin, faecal occult blood test, and the occurrence of melaena were assessed. Faecal calprotectin ≥ 50 µg/g was considered elevated. RESULTS: Melaena was reported by all healthy volunteers after 300 ml and by 11/15 healthy volunteers (71%) after 100 ml blood ingestion. One day after ingestion of 300 ml blood, 8/16 faecal calprotectin tests were positive compared to 1/16 at baseline (p = 0.016). Faecal calprotectin levels above > 200 µg/g were rarely observed. There was a trend for faecal calprotectin test positivity also after ingestion of 100 ml. CONCLUSION:
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Authors | Stephan R Vavricka, Henriette Heinrich, Simon Buetikofer, Flavia Breitenmoser, Emanuel Burri, Xiaoye Schneider-Yin, Jasmin Barman-Aksoezen, Luc Biedermann, Michael Scharl, Jonas Zeitz, Gerhard Rogler, Benjamin Misselwitz, Matthias Sauter |
Journal | United European gastroenterology journal
(United European Gastroenterol J)
Vol. 6
Issue 7
Pg. 1007-1014
(Aug 2018)
ISSN: 2050-6406 [Print] England |
PMID | 30228888
(Publication Type: Journal Article)
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