Abstract | PURPOSE: MATERIAL AND METHODS: This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. One hundred children aged 2-8 years with HSGS were randomly classified into 2 groups; study group: treated with honey plus oral acyclovir and control group: treated with oral acyclovir alone. Severity of oral lesions, Fever, eating and drinking ability, pain scores and need for analgesics were compared between 2 groups on day 3, 5 and 7 after starting treatment. RESULTS: Children receiving honey plus acyclovir (i.e. study group) had significantly earlier disappearance of herpetic oral lesions; median 3 days vs. 6 days in control group (P = 0.022), drooling; 2 days vs. 4 days (P = 0.030) and eating difficulty; 3 days vs. 8 days (P = 0.001). Study group also had significantly lower pain scores, better eating and drinking ability and significantly less need for analgesics at 3 time-points of assessment. Fever disappeared in both groups with no statistically significant difference. CONCLUSIONS:
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Authors | Osama G Abdel-Naby Awad, Abdel-Monem H Hamad |
Journal | American journal of otolaryngology
(Am J Otolaryngol)
2018 Nov - Dec
Vol. 39
Issue 6
Pg. 759-763
ISSN: 1532-818X [Electronic] United States |
PMID | 30227969
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2018 Elsevier Inc. All rights reserved. |
Chemical References |
- Antiviral Agents
- Acyclovir
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Topics |
- Acyclovir
(therapeutic use)
- Administration, Oral
- Antiviral Agents
(therapeutic use)
- Apitherapy
- Child
- Child, Preschool
- Combined Modality Therapy
- Double-Blind Method
- Female
- Honey
- Humans
- Male
- Prospective Studies
- Stomatitis, Herpetic
(therapy)
- Treatment Outcome
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