Abstract |
1-Nitropyrene (1-NP) is a widely distributed pollutant in the environment and is best known for its mutagenicity and carcinogenicity. In this study, we evaluated the effects of 1-NP exposure in different gestational stages on the pregnant outcomes. Pregnant mice were administered with 1-NP by gavage daily in early (GD1-GD6), middle (GD7-GD12) or late pregnancy (GD13-GD17), respectively. We found that gestational 1-NP exposure had no effect on implantation sites per litter, preterm delivery and fetal death. Interestingly, mice exposed to 1-NP in late pregnancy showed a significant reduction in fetal weight and crown-rump length. Correspondingly, placental weight and diameter were markedly reduced in dams exposed to 1-NP in late pregnancy. Additional experiment showed maternal 1-NP exposure in late pregnancy reduced blood sinusoid area of placental labyrinthine region in a dose-dependent manner. Although gestational 1-NP exposure had little effect on placental cell apoptosis, as determined by the TUNEL assay, the rate of Ki67-positive cell, a marker of cell proliferation, was reduced in placental labyrinthine region of mice exposed to 1-NP in late pregnancy. These findings provide evidence that gestational 1-NP exposure induces fetal growth restriction in a stage-dependent manner. Placenta is a toxic target in the process of 1-NP-induced fetal growth restriction.
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Authors | Ran Li, Xilu Wang, Bo Wang, Jian Li, Yaping Song, Biao Luo, Yuanhua Chen, Cheng Zhang, Hua Wang, Dexiang Xu |
Journal | Chemosphere
(Chemosphere)
Vol. 213
Pg. 252-258
(Dec 2018)
ISSN: 1879-1298 [Electronic] England |
PMID | 30223130
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
- Mutagens
- Pyrenes
- 1-nitropyrene
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Topics |
- Animals
- Cell Proliferation
- Female
- Fetal Growth Retardation
(chemically induced)
- Mice
- Mutagens
(adverse effects)
- Placenta
(drug effects)
- Pregnancy
- Pyrenes
(adverse effects)
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