Abstract | PURPOSE: METHODS: Between 2009 and 2015, we consecutively enrolled 52 patients with lung cancer, who underwent pleurodesis to treat MPE and were analyzed retrospectively. On day 1, 100 mg of Helixor-M was instilled via pleural catheter. If the procedure was not effective, it was repeated every other day up to five times, and the dose increased each time by 100 mg. The primary study outcome was reappearance of pleural effusion at 1 month after the last pleurodesis procedure. RESULTS: The median age of patient was 63 years, and 77% of the 52 patients were male. About 85% of pleural effusions were found to be malignant by cytogenetic analysis. Forty-two (81%) patients were evaluable for recurrence of MPE. The 1-month recurrence rate was 48% (20/42). Among the 20 patients who developed recurrent MPE, 6 required therapeutic thoracentesis. Thirteen (25%) patients experienced procedure-related pain requiring medication. Eight (15%) had fever > 38 °C. CONCLUSIONS:
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Authors | Yun-Gyoo Lee, Ina Jung, Dong-Hoe Koo, Du-Young Kang, Tae Yoon Oh, Sukjoong Oh, Seung-Sei Lee |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 27
Issue 5
Pg. 1945-1949
(May 2019)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 30218188
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Drainage
(methods)
- Female
- Humans
- Lung Neoplasms
(complications, drug therapy, pathology, therapy)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy)
- Plant Extracts
(administration & dosage, adverse effects)
- Pleural Effusion, Malignant
(drug therapy, pathology)
- Pleurodesis
(methods)
- Republic of Korea
- Retrospective Studies
- Treatment Outcome
- Viscum album
(chemistry)
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