Influence of swine leukocyte antigen haplotype on serum antibody titers against swine erysipelas vaccine and reproductive and meat production traits of SLA-defined selectively bred Duroc pigs.

Abstract

We investigated possible associations of SLA class II haplotypes with serum antibody titers against a swine erysipelas vaccine, reproductive and meat production traits using a population of selective breeding Duroc pigs. In the selective breeding Duroc pigs, four SLA class II-DRB1 and -DQB1 alleles were assigned by using PCR-sequence specific primer technique. Low-resolution haplotype (Lr)-0.30 and/or Lr-0.13 were deduced from the SLA class II alleles in the population of SLA-defined Duroc pigs. SLA-homozygous piglets with the Lr-0.30 haplotype had relatively lower serum antibody titers against the vaccine compared to those with Lr-0.13. In contrast, there were no statistically significant differences in reproductive performance between the SLA-defined pigs with two SLA class II haplotypes. Weaning and rearing rates until the body weight of 105 kg was reached in homozygous piglets with Lr-0.30 were significantly lower than those in homozygous piglets with Lr-0.13. The SLA-defined pigs had lower birth and weaning weights, body weights at 60 days of age, and daily weight gains than non-selective breeding Duroc pigs. Furthermore, the SLA-defined pigs had slightly lower back fat thickness compared to the non-selective breeding pigs. The rib eye areas of homozygous or heterozygous pigs with Lr-0.13 were larger than those of homozygous pigs with Lr-0.30 and non-selective breeding pigs. These data suggested that SLA haplotypes had the potential as useful genetic markers for selective breeding in the population of SLA-defined Duroc pigs.

• Authors: Noriaki Imaeda, Asako Ando, Masaki Takasu, Tatsuya Matsubara, Naohito Nishii, Satoshi Takashima, Atsuko Shigenari, Takashi Shiina, Hitoshi Kitagawa
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 80 Issue 11 Pg. 1662-1668 (Nov 09 2018) ISSN: 1347-7439 [Electronic] Japan
• PMID: 30210067 (Publication Type: Journal Article)

Chemical References

• Antibodies, Bacterial
• Bacterial Vaccines
• Histocompatibility Antigens Class I
• swine leukocyte antigen

Topics

• Agriculture
• Animals
• Antibodies, Bacterial (blood, immunology)
• Bacterial Vaccines (immunology)
• Breeding
• Female
• Haplotypes
• Histocompatibility Antigens Class I (immunology)
• Male
• Red Meat
• Reproduction
• Swine
• Swine Erysipelas (immunology)