Unexpected higher blood loss associated with higher dose ε-aminocaproic acid in pediatric scoliosis surgery.

Abstract

The purpose of this study was to determine if a higher dosing of ε-aminocaproic acid (EACA) is associated with less perioperative blood loss than a lower dose. A total of 74 patients having scoliosis surgery were analyzed. Of the 74 patients, 36 patients received EACA (10 mg/kg/h) and 38 patients received EACA (33 mg/kg/h). After controlling for key variables, an infusion of 33 mg/kg/h of EACA was associated with an increase in intraoperative blood loss of 8.1 ml/kg compared with an infusion of 10 mg/kg/h of EACA. A 33 mg/kg/h intraoperative infusion is associated with higher intraoperative blood loss than an infusion at 10 mg/kg/h.

• Authors: Humphrey Lam, Thomas Austin, Thanh Nguyen, Jeffrey Martus, Jonathan Schoenecker
• Journal: Journal of pediatric orthopedics. Part B (J Pediatr Orthop B) Vol. 28 Issue 1 Pg. 40-44 (Jan 2019) ISSN: 1473-5865 [Electronic] United States
• PMID: 30199414 (Publication Type: Journal Article)

Chemical References

• Antifibrinolytic Agents
• Aminocaproic Acid

Topics

• Adolescent
• Aminocaproic Acid (administration & dosage, adverse effects)
• Antifibrinolytic Agents (administration & dosage, adverse effects)
• Blood Loss, Surgical
• Dose-Response Relationship, Drug
• Female
• Humans
• Infusions, Intravenous
• Male
• Retrospective Studies
• Scoliosis (surgery)