Abstract | AIMS/HYPOTHESES: Our aim was to examine the independent and combined (cross-sectional) associations of sedentary time (ST), higher intensity physical activity (HPA) and cardiorespiratory fitness (CRF) with metabolic syndrome and diabetes status. METHODS: In 1933 adults (aged 40-75 years) ST and HPA (surrogate measure for moderate to vigorous physical activity) were measured with the activPAL3. CRF was assessed by submaximal cycle-ergometer testing. Metabolic syndrome was defined according to the Adult Treatment Panel ( ATP) III guidelines. Diabetes status (normal, prediabetes [i.e. impaired glucose tolerance and/or impaired fasting glucose] or type 2 diabetes) was determined from OGTT. (Multinomial) logistic regression analyses were used to calculate likelihood for the metabolic syndrome, prediabetes and type 2 diabetes according to ST, HPA and CRF separately and combinations of ST-CRF and HPA-CRF. RESULTS: Higher ST, lower HPA and lower CRF were associated with greater odds for the metabolic syndrome and type 2 diabetes independently of each other. Compared with individuals with high CRF and high HPA (CRFhigh-HPAhigh), odds for the metabolic syndrome and type 2 diabetes were higher in groups with a lower CRF regardless of HPA. Individuals with low CRF and low HPA (CRFlow-HPAlow) had a particularly high odds for the metabolic syndrome (OR 5.73 [95% CI 3.84, 8.56]) and type 2 diabetes (OR 6.42 [95% CI 3.95, 10.45]). Similarly, compared with those with high CRF and low ST (CRFhigh-STlow), those with medium or low CRF had higher odds for the metabolic syndrome, prediabetes and type 2 diabetes, irrespective of ST. In those with high CRF, high ST was associated with significantly high odds for the metabolic syndrome (OR 2.93 [95% CI 1.72, 4.99]) and type 2 diabetes (OR 2.21 [95% CI 1.17, 4.17]). The highest odds for the metabolic syndrome and type 2 diabetes were observed in individuals with low CRF and high ST (CRFlow-SThigh) (OR [95% CI]: the metabolic syndrome, 9.22 [5.74, 14.80]; type 2 diabetes, 8.38 [4.83, 14.55]). CONCLUSIONS/INTERPRETATION:
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Authors | Jeroen H P M van der Velde, Nicolaas C Schaper, Coen D A Stehouwer, Carla J H van der Kallen, Simone J S Sep, Miranda T Schram, Ronald M A Henry, Pieter C Dagnelie, Simone J P M Eussen, Martien C J M van Dongen, Hans H C M Savelberg, Annemarie Koster |
Journal | Diabetologia
(Diabetologia)
Vol. 61
Issue 12
Pg. 2561-2569
(12 2018)
ISSN: 1432-0428 [Electronic] Germany |
PMID | 30198051
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Accelerometry
- Adult
- Aged
- Blood Glucose
(analysis)
- Cardiorespiratory Fitness
(physiology)
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(metabolism, physiopathology)
- Exercise
(physiology)
- Female
- Humans
- Logistic Models
- Male
- Metabolic Syndrome
(metabolism, physiopathology)
- Middle Aged
- Sedentary Behavior
- Surveys and Questionnaires
- Waist Circumference
(physiology)
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