Chronic dietary lithium induces increased levels of myo-inositol-1-phosphatase activity in rat cerebral cortex homogenates.

Abstract

The monovalent lithium ion inhibits the enzyme myo-inositol-1-phosphatase at concentrations comparable to those which are useful in the treatment of manic depressive illness. However, dialyzed cortical homogenates from rats which have been fed diets containing lithium carbonate demonstrate increased myo-inositol-1-phosphate phosphatase activity. Over a 4-week period, there is an approximate doubling of the lithium-sensitive myo-inositol-1-phosphatase activity in the homogenate.

• Authors: P F Renshaw, N E Joseph, J S Leigh Jr
• Journal: Brain research (Brain Res) Vol. 380 Issue 2 Pg. 401-4 (Aug 20 1986) ISSN: 0006-8993 [Print] Netherlands
• PMID: 3019470 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Lithium
• Phosphoric Monoester Hydrolases
• myo-inositol-1 (or 4)-monophosphatase

Topics

• Animals
• Cerebral Cortex (drug effects, enzymology)
• Diet
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Lithium (administration & dosage, toxicity)
• Phosphoric Monoester Hydrolases (metabolism)
• Rats
• Time Factors