Abstract | OBJECTIVES: STUDY DESIGN: Retrospective study. METHODS: We used ETV6-NTRK3 gene fusion analyses to reclassify 19 parotid gland tumors that had previously been diagnosed as SC or ACC, and then investigated hemorrhage in both hematoxylin- eosin (H&E)-stained sections and MRIs, and immunohistochemical expression of S-100, mammaglobin, DOG1, and α- amylase. RESULTS: The 19 tumors were genetically reclassified into 11 (58%) SC and 8 (42%) ACC. Combined S-100 and mammaglobin were specific for SC; whereas DOG1 was specific for ACC, and α- amylase was expressed only in 4 ACC cases (50%). H&E staining showed hemorrhage with hemosiderin deposition in all SC cases, and T2-weighted MRI showed hypointense areas in all investigated SC cases, but not in ACC. CONCLUSION:
Hemorrhage with hemosiderin deposition is frequently present in SC, and hemorrhage findings in MRI and an immunohistochemical panels for S-100, mammaglobin and DOG1 can distinguish SC from ACC. LEVEL OF EVIDENCE: 3b.
|
Authors | Hiroko Kuwabara, Kiyohito Yamamoto, Tetsuya Terada, Ryo Kawata, Toshitaka Nagao, Yoshinobu Hirose |
Journal | Laryngoscope investigative otolaryngology
(Laryngoscope Investig Otolaryngol)
Vol. 3
Issue 4
Pg. 268-274
(Aug 2018)
ISSN: 2378-8038 [Print] United States |
PMID | 30186957
(Publication Type: Journal Article)
|