Pharmacological profiles of a potential LTB4-antagonist, SM-9064.

Abstract

Antagonistic activity against leukotriene B4 (LTB4) and other pharmacological activities of SM-9064 were studied in vitro and in vivo. It inhibited the chemotaxis of rat polymorphonuclear leukocytes (PMNLs) induced by LTB4 (IC50 = 1.3 X 10(-7) M, not by other chemoattractants. Its agonistic activity was much less than that of LTB4. It suppressed the Arthus reaction-induced inflammation in mice with the dose of 5 mg/kg, i.p. or 10 mg/kg, p.o. These results suggest that SM-9064 is a candidate of LTB4 antagonists, which is effective in some type of inflammation.

• Authors: M Namiki, Y Igarashi, K Sakamoto, T Nakamura, Y Koga
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 138 Issue 2 Pg. 540-6 (Jul 31 1986) ISSN: 0006-291X [Print] United States
• PMID: 3017332 (Publication Type: Journal Article)

Chemical References

• Fatty Acids, Unsaturated
• SM 9064
• Leukotriene B4
• Levamisole
• N-Formylmethionine Leucyl-Phenylalanine

Topics

• Animals
• Chemotaxis, Leukocyte (drug effects)
• Fatty Acids, Unsaturated (pharmacology)
• In Vitro Techniques
• Kinetics
• Leukotriene B4 (antagonists & inhibitors, pharmacology)
• Levamisole (pharmacology)
• Male
• N-Formylmethionine Leucyl-Phenylalanine (pharmacology)
• Neutrophils (drug effects, physiology)
• Rats
• Rats, Inbred Strains
• Structure-Activity Relationship