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Carbohydrate Loading to Combat Acute Pancreatitis.

Abstract
Acute pancreatitis is characterized by ATP deficiency and sustained Ca2+ overload in pancreatic acinar cells, leading to premature zymogen activation, auto-digestion of the pancreas, and necrosis. Recent research reveals a rational approach to ameliorate disease through galactose feeding, bypassing hexokinases to restore ATP levels and Ca2+ homeostasis, thereby reducing disease markers.
AuthorsTim Vervliet, David I Yule, Geert Bultynck
JournalTrends in biochemical sciences (Trends Biochem Sci) Vol. 43 Issue 10 Pg. 741-744 (10 2018) ISSN: 0968-0004 [Print] England
PMID30170888 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Comment)
CopyrightCopyright © 2018 Elsevier Ltd. All rights reserved.
Chemical References
  • Galactose
Topics
  • Acute Disease
  • Animals
  • Diet, Carbohydrate Loading
  • Galactose
  • Mice
  • Pancreatitis

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