Abstract |
Acute pancreatitis is characterized by ATP deficiency and sustained Ca2+ overload in pancreatic acinar cells, leading to premature zymogen activation, auto-digestion of the pancreas, and necrosis. Recent research reveals a rational approach to ameliorate disease through galactose feeding, bypassing hexokinases to restore ATP levels and Ca2+ homeostasis, thereby reducing disease markers.
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Authors | Tim Vervliet, David I Yule, Geert Bultynck |
Journal | Trends in biochemical sciences
(Trends Biochem Sci)
Vol. 43
Issue 10
Pg. 741-744
(10 2018)
ISSN: 0968-0004 [Print] England |
PMID | 30170888
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Comment)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Acute Disease
- Animals
- Diet, Carbohydrate Loading
- Galactose
- Mice
- Pancreatitis
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