High level of serum Cripto-1 in hepatocellular carcinoma, especially with hepatitis B virus infection.

Abstract

BACKGROUND:

Human Cripto-1 (CR-1), a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic protein family (EGF-CFC), is highly expressed in a variety of human cancers. We aimed to detect serum CR-1 level in liver diseases especially in hepatocellular carcinoma (HCC) patients.

METHODS:

Serum CR-1 level was Sandwich-type enzyme-linked immuno sorbent assay (ELISA) detected in 330 patients with liver diseases including HCC, cirrhosis, and chronic hepatitis and 50 volunteers without hepatitis B virus (HBV) or hepatitis C virus (HCV) infection as control.

RESULTS:

The serum CR-1 level was significantly higher in HCC patients than volunteer controls and it was also significantly higher in HBV-related HCC than HCV-related HCC. In addition, serum CR-1 level was correlated with serum alpha-feto-protein (AFP) in HBV-related HCC patients. The serum CR-1 was also higher in cirrhosis and chronic hepatitis than volunteer controls. The serum CR-1 in HBV-related cirrhosis was higher than chronic hepatitis B, but there was no significant difference between HCV-related cirrhosis and chronic hepatitis C.

CONCLUSIONS:

Serum CR-1 was higher in HCC patients and might serve as a complementary biomarker to clinical diagnosis of HBV-related HCC. The high level of serum CR-1 in HBV-related liver disease might be partly attributed to HBV infection.

• Authors: Yingyu Zhang, Hongqin Xu, Xiumei Chi, Yuxiang Fan, Ying Shi, Junqi Niu
• Journal: Medicine (Medicine (Baltimore)) Vol. 97 Issue 35 Pg. e11781 (Aug 2018) ISSN: 1536-5964 [Electronic] United States
• PMID: 30170372 (Publication Type: Journal Article)

Chemical References

• GPI-Linked Proteins
• Intercellular Signaling Peptides and Proteins
• Neoplasm Proteins
• TDGF1 protein, human

Topics

• Adult
• Carcinoma, Hepatocellular (blood, virology)
• Case-Control Studies
• Female
• GPI-Linked Proteins (blood)
• Hepatitis B, Chronic (blood, complications)
• Hepatitis C, Chronic (blood, complications)
• Humans
• Intercellular Signaling Peptides and Proteins (blood)
• Liver Cirrhosis (blood, virology)
• Liver Neoplasms (blood, virology)
• Male
• Middle Aged
• Neoplasm Proteins (blood)