Precision of VerifyNow P2Y12 Assessment of Clopidogrel Response in Patients Undergoing Cerebral Aneurysm Flow Diversion.

Abstract

BACKGROUND:

Dual antiplatelet therapy (DAT), most commonly with aspirin and Clopidogrel, is the standard of care for intracranial stenting, including flow diversion. Clopidogrel response varies by individual.

OBJECTIVE:

To investigate the real-world precision of VerifyNow P2Y12 assessment (Accumetrics, San Diego, California) of Clopidogrel response.

METHODS:

Using a prospectively-collected, IRB-approved cerebral aneurysm database 643 patients were identified who were treated with the Pipeline embolization device from 2011 to 2017. Patients with multiple P2Y12 assays drawn within a 24-h window were identified. A single patient could contribute multiple, independent sets. Levels drawn before a 5-d course of DAT and patients who received alternative antiplatelet agents were excluded. Therapeutic range was defined as platelet reaction units (PRU) 60-200.

RESULTS:

A total of 1586 P2Y12 measurements were recorded; 293 (46%) patients had more than one assay. One hundred forty (22%) patients had multiple P2Y12 measurements within 24 h. These patients accounted for 230 independent 24-h sets. The average P2Y12 fluctuation across all sets was 35 points; the 25th, 50th, and 75th percentiles were 12, 26, and 48 points, respectively. Of the 230 24-h sets of P2Y12 assays, 76% remained within their original therapeutic category: 100 (43%) all therapeutic, 54 (23%) all hypo-responsive, and 21 (9%) all hyper-responsive. Twenty-four percent of patients fluctuated between therapeutic categories when multiple P2Y12 assessments were drawn within a 24-h period: 29 (13%) between hypo-response and therapeutic, 23 (10%) between hyper-response and therapeutic, and 3 (1%) between hypo-response and hyper-response.

CONCLUSION:

Our experience suggests P2Y12 is an often-imprecise measure, and this should be considered when utilizing P2Y12 levels for clinical decisions.

• Authors: Matthew T Bender, David A Zarrin, Jessica K Campos, Bowen Jiang, Arun Chandra, Chau D Vo, Justin M Caplan, Judy Huang, Rafael J Tamargo, Li-Mei Lin, Geoffrey P Colby, Alexander L Coon
• Journal: Neurosurgery (Neurosurgery) Vol. 85 Issue 4 Pg. 543-549 (10 01 2019) ISSN: 1524-4040 [Electronic] United States
• PMID: 30169782 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 by the Congress of Neurological Surgeons.

Chemical References

• P2RY12 protein, human
• Platelet Aggregation Inhibitors
• Receptors, Purinergic P2Y12
• Clopidogrel
• Aspirin

Topics

• Aged
• Aspirin (therapeutic use)
• Blood Coagulation Tests (methods, standards)
• California
• Clopidogrel (therapeutic use)
• Embolization, Therapeutic
• Female
• Humans
• Intracranial Aneurysm (therapy)
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (therapeutic use)
• Receptors, Purinergic P2Y12 (analysis)
• Stents