Abstract | BACKGROUND: OBJECTIVES: We sought to develop a cost-effective, battery-powered, fiber-coupled PDT system suitable for intraoral light delivery enabled by smartphone interface and embedded electronics for ease of operation. METHODS: Device performance was assessed in measurements of optical power output, spectral stability, and preclinical assessment of PDT response in ALA-photosensitized squamous carcinoma cell cultures and murine subcutaneous tumor xenografts. RESULTS: The system achieves target optoelectronic performance with a stable battery-powered output of approximately 180 mW from the fiber tip within the desired spectral window for PpIX activation. The device has a compact configuration, user friendly operation and flexible light delivery for the oral cavity. In cell culture, we show that the overall dose-response is consistent with established light sources and complete cell death of ALA photosensitized cells can be achieved in the irradiated zone. In vivo PDT response (reduction in tumor volume) is comparable with a commercial 635 nm laser. CONCLUSIONS: We developed a low-cost, LED-based, fiber-coupled PDT light delivery source that has stable output on battery power and suitable form factor for deployment in rural and/or resource-limited settings. Lasers Surg. Med. 9999:1-7, 2018. © 2018 Wiley Periodicals, Inc.
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Authors | Hui Liu, Liam Daly, Grant Rudd, Amjad P Khan, Srivalleesha Mallidi, Yiran Liu, Filip Cuckov, Tayyaba Hasan, Jonathan P Celli |
Journal | Lasers in surgery and medicine
(Lasers Surg Med)
Vol. 51
Issue 4
Pg. 345-351
(04 2019)
ISSN: 1096-9101 [Electronic] United States |
PMID | 30168618
(Publication Type: Evaluation Study, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2018 Wiley Periodicals, Inc. |
Chemical References |
- Antineoplastic Agents
- Photosensitizing Agents
- Aminolevulinic Acid
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Topics |
- Aminolevulinic Acid
(therapeutic use)
- Animals
- Antineoplastic Agents
(therapeutic use)
- Carcinoma, Squamous Cell
(drug therapy)
- Cell Line, Tumor
- Developing Countries
- Female
- Humans
- Light
- Mice
- Mice, Nude
- Mouth Neoplasms
(drug therapy)
- Optical Fibers
- Photochemotherapy
(instrumentation, methods)
- Photosensitizing Agents
(therapeutic use)
- Smartphone
- Treatment Outcome
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