Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature.

Abstract

Gastric antral vascular ectasia (GAVE) is a rare cause of chronic gastric hemorrhaging and iron deficiency anemia and is characterized by a distinctive endoscopic appearance. The main treatment of GAVE is endoscopic; however, medication is necessary in refractory cases. We herein report a 69-year-old woman with systemic sclerosis (SSc) who developed recurrent severe anemia after endoscopic treatment of GAVE that was successfully managed using intravenous cyclophosphamide (IVCY). The recurrence of GAVE after discontinuation of IVCY was successfully managed using a combination of IVCY and endoscopic treatment, without blood transfusion. Long-term IVCY may be indicated for refractory GAVE associated with SSc.

• Authors: Yuki Matsumoto, Haeru Hayashi, Koichiro Tahara, Takuya Yasuda, Shoko Tsubouchi, Yusuke Yamamoto, Takahiro Mizuuchi, Hiroaki Mori, Tetsuji Sawada
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 58 Issue 1 Pg. 135-139 (Jan 01 2019) ISSN: 1349-7235 [Electronic] Japan
• PMID: 30101944 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Immunosuppressive Agents
• Cyclophosphamide

Topics

• Administration, Intravenous
• Aged
• Cyclophosphamide (administration & dosage)
• Female
• Gastric Antral Vascular Ectasia (drug therapy)
• Humans
• Immunosuppressive Agents (administration & dosage)
• Recurrence
• Scleroderma, Systemic (complications)
• Treatment Outcome