Killer-cell immunoglobulin-like receptors associated with polycystic ovary syndrome.

Abstract

Polycystic ovary syndrome (PCOS) affects the endocrine system and is associated with low-grade inflammation. Natural killer (NK) cells are involved in the defense of the female reproductive tract, folliculogenesis, ovulation and the menstrual cycle. The killer-cell immunoglobulin-like receptors (KIR) on the surface of NK cells modulate the activation and function of these cells after interacting with human leukocyte antigen (HLA) class I ligands. The objective of this study was to evaluate the possible association of the KIR and their HLA ligands with polycystic ovary syndrome.

METHODS:

Ninety-three patients with PCOS according to the Rotterdam criteria and 104 healthy controls were included in this study. The HLA class I and KIR genotypes were determined using a PCR-SSO technique, rSSO Luminex®. In order to assess whether the distribution of the HLA and KIR genotypes was in Hardy-Weinberg equilibrium, Arlequin 3.1 software was used. The frequency distributions in the two study groups were compared using the chi-squared statistic with Yates´s correction using Open Epi software.

RESULTS:

The higher frequencies of KIR3DS1-Bw4 (41% vs. 19%, Pc = 0.002; OR = 2.90) and homozygotic KIR2DS4-del (54% vs. 26%, Pc = 0.0002; OR = 3.316) in patients compared with controls suggest they confer susceptibility to PCOS. A lower frequency of KIR2DS4-full was observed in patients (43% vs. 70%, Pc = 0.0004, OR = 0.320).

CONCLUSION:

KIR and its HLA ligands were associated with the development of PCOS in the studied population.

• Authors: Laise Nayana Sala Elpidio, Josiane Bazzo de Alencar, Patrícia Yumeko Tsuneto, Hugo Vicentin Alves, Mariana Trento Toretta, Sérgio Ken It Taura, Jeane Eliete Laguila Visentainer, Ana Maria Sell
• Journal: Journal of reproductive immunology (J Reprod Immunol) Vol. 130 Pg. 1-6 (11 2018) ISSN: 1872-7603 [Electronic] Ireland
• PMID: 30099219 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Epitopes
• Histocompatibility Antigens Class I
• KIR2DS4 protein, human
• KIR3DS1 protein, human
• Receptors, KIR
• Receptors, KIR3DS1

Topics

• Adult
• Case-Control Studies
• Epitopes (genetics, immunology)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotyping Techniques
• Histocompatibility Antigens Class I (immunology, metabolism)
• Homozygote
• Humans
• Killer Cells, Natural (immunology, metabolism)
• Polycystic Ovary Syndrome (genetics, immunology)
• Receptors, KIR (genetics, immunology)
• Receptors, KIR3DS1 (genetics, immunology)
• Young Adult