Abstract |
Whether there is a causal relationship between milk intake and acne is unknown. We tested the hypothesis that genetically determined milk intake is associated with acne in adults using a Mendelian randomization design. LCT-13910 C/T (rs4988235) is associated with lactase persistence (TT/TC) in Northern Europeans. We investigated the association between milk intake, LCT-13910 C/T (rs4988235), and acne in 20,416 adults (age-range: 20⁻96) from The Danish General Suburban Population Study (GESUS). The adjusted observational odds ratio for acne in any milk intake vs. no milk intake was 0.93(95% confidence interval: 0.48⁻1.78) in females and 0.49(0.22⁻1.08) in males aged 20⁻39 years, and 1.15(95% confidence interval: 0.66⁻1.99) in females and 1.02(0.61⁻1.72) in males above 40 years. The unadjusted odds ratio for acne in TT+TC vs. CC was 0.84(0.43⁻1.62) in the age group 20⁻39 years, and 0.99(0.52⁻1.88) above 40 years. We did not find any observational or genetic association between milk intake and acne in our population of adults.
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Authors | Christian R Juhl, Helle K M Bergholdt, Iben M Miller, Gregor B E Jemec, Jørgen K Kanters, Christina Ellervik |
Journal | Nutrients
(Nutrients)
Vol. 10
Issue 8
(Aug 08 2018)
ISSN: 2072-6643 [Electronic] Switzerland |
PMID | 30096803
(Publication Type: Journal Article, Observational Study)
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Chemical References |
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Topics |
- Acne Vulgaris
(diagnosis, enzymology, epidemiology, genetics)
- Adult
- Aged
- Aged, 80 and over
- Animals
- Cross-Sectional Studies
- Denmark
(epidemiology)
- Female
- Genetic Predisposition to Disease
- Humans
- Lactase
(genetics, metabolism)
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Milk
(adverse effects)
- Phenotype
- Polymorphism, Single Nucleotide
- Risk Factors
- Young Adult
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