Abstract | PURPOSE OF REVIEW:
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of mature T-cell and natural killer (NK)-cell neoplasms in the WHO 2016 classification. Patient prognosis is poor when treated with CHOP, and there is an unmet need for new drugs. Several agents have been developed for PTCL, and their use is the subject of this review. RECENT FINDINGS: SUMMARY: Treatment remains a challenge for PTCL, and several targeted drugs provide new approaches. Progress will be made incrementally in the different subtypes. One of the critical situations facing new drugs is the ability to run robust clinical trials in rare diseases.
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Authors | Christian Gisselbrecht, David Sibon |
Journal | Current opinion in oncology
(Curr Opin Oncol)
Vol. 30
Issue 5
Pg. 285-291
(09 2018)
ISSN: 1531-703X [Electronic] United States |
PMID | 30096094
(Publication Type: Journal Article, Review)
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Chemical References |
- 10-propargyl-10-deazaaminopterin
- Depsipeptides
- Hydroxamic Acids
- Immunoconjugates
- Sulfonamides
- Brentuximab Vedotin
- romidepsin
- belinostat
- Aminopterin
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Topics |
- Aminopterin
(administration & dosage, analogs & derivatives)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Brentuximab Vedotin
- Clinical Trials, Phase II as Topic
- Depsipeptides
(administration & dosage)
- Humans
- Hydroxamic Acids
(administration & dosage)
- Immunoconjugates
(administration & dosage)
- Lymphoma, T-Cell, Peripheral
(drug therapy, immunology, radiotherapy, therapy)
- Randomized Controlled Trials as Topic
- Sulfonamides
(administration & dosage)
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