Flavonoids, Sterols and Lignans from Cochlospermum vitifolium and Their Relationship with Its Liver Activity.

Abstract

The sterols β-sitostenone (1), stigmast-4,6,8(14),22-tetraen-3-one (2), β-sitosterol (3) and stigmasterol (4), the aromatic derivatives antiarol (5) and gentisic acid (6), the phenylpropanes coniferyl alcohol (7), epoxyconiferyl alcohol (8) and ferulic acid (9), the apocarotenoid vomifoliol (10), the flavonoids naringenin (11), 7,4'-dimethoxytaxifolin (7,4'-dimethoxydihydroquercetin, 12), aromadendrin (13), kaempferol (14), taxifolin (dihydroquercetin, 15), prunin (naringenin-7-O-β-d-glucoside, 16), populnin (kaempferol-7-O-β-d-glucoside, 17) and senecin (aromadendrin-7-O-β-d-glucoside, 18) and the lignans kobusin (19) and pinoresinol (20), were isolated from the dried bark of Cochlospermum vitifolium Spreng (Cochlospermaceae), a Mexican medicinal plant used to treat jaundice, liver ailments and hepatitis C. Fourteen of these compounds were isolated for the first time from this plant and from the Cochlospermum genus. Compounds 3⁻4, 6⁻7, 9⁻11, 13⁻17 and 20 have previously exhibited diverse beneficial liver activities. The presence of these compounds in C. vitifolium correlates with the use of this Mexican medicinal plant.

• Authors: A Berenice Aguilar-Guadarrama, María Yolanda Rios
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 23 Issue 8 (Aug 05 2018) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 30081608 (Publication Type: Journal Article)

Chemical References

• Flavonoids
• Lignans
• Plant Extracts
• Sterols

Topics

• Animals
• Bixaceae (chemistry)
• Flavonoids (chemistry, pharmacology, therapeutic use)
• Humans
• Lignans (chemistry, pharmacology, therapeutic use)
• Liver (drug effects, metabolism)
• Plant Bark (chemistry)
• Plant Extracts (chemistry, pharmacology, therapeutic use)
• Plants, Medicinal (chemistry)
• Sterols (chemistry, pharmacology, therapeutic use)