Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review.

Abstract

Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has strong antioxidative, anti-inflammatory, and antibacterial properties. Due to these properties, curcumin has been used as a remedy for the prevention and treatment of skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer. Curcumin has protective effects against skin damage caused by chronic ultraviolet B radiation. One of the challenges in maximizing the therapeutic potential of curcumin is its low bioavailability, limited aqueous solubility, and chemical instability. In this regard, the present review is focused on recent studies concerning the use of curcumin for the treatment of skin diseases, as well as offering new and efficient strategies to optimize its pharmacokinetic profile and increase its bioavailability.

• Authors: Yunes Panahi, Omid Fazlolahzadeh, Stephen L Atkin, Muhammed Majeed, Alexandra E Butler, Thomas P Johnston, Amirhossein Sahebkar
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 234 Issue 2 Pg. 1165-1178 (02 2019) ISSN: 1097-4652 [Electronic] United States
• PMID: 30073647 (Publication Type: Journal Article, Review)
• Copyright: © 2018 Wiley Periodicals, Inc.

Chemical References

• Dermatologic Agents
• Curcumin

Topics

• Animals
• Biological Availability
• Curcumin (adverse effects, analogs & derivatives, pharmacokinetics, therapeutic use)
• Dermatologic Agents (adverse effects, pharmacokinetics, therapeutic use)
• Humans
• Skin (drug effects, metabolism, pathology)
• Skin Diseases (drug therapy, metabolism, pathology)
• Treatment Outcome