Chitinase-3-like Protein 1 (YKL-40) Expression in Squamous Cell Skin Cancer.

Abstract

BACKGROUND/AIM:

YKL-40 plays a role in proliferation and differentiation of malignant cells. The aim of this study was to examine whether YKL-40 is expressed in cutaneous squamous cell carcinoma (SCC).

MATERIALS AND METHODS:

The study was based on histologically-confirmed biopsies of cutaneous SCCs obtained from 38 patients. The tissue expression of YKL-40 was assessed using an immunohisto-chemical method. The percentage of cells showing a positive reaction as well as the intensity of the IHC reaction was assessed using the immunoreactive score developed by Remmele and Stegner.

RESULTS:

All samples of cutaneous SCCs showed cytoplasmic expression of YKL-40. The intensity of YKL-40 expression varied between 1 and 8 points, according to the applied scale. In the majority of cancers about 10-80% of tumor cells were positive for YKL-40. The intensity of the reaction was low (20 samples, 52.6%) or medium (18 samples, 47.4%).

CONCLUSION:

YKL-40 is expressed in cutaneous SCC. Further research is needed to establish the value of YKL-40 for diagnosis and monitoring of SCC.

• Authors: Joanna Salomon, Aleksandra Piotrowska, Łukasz Matusiak, Piotr Dzięgiel, Jacek C Szepietowski
• Journal: Anticancer research (Anticancer Res) Vol. 38 Issue 8 Pg. 4753-4758 (Aug 2018) ISSN: 1791-7530 [Electronic] Greece
• PMID: 30061245 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• CHI3L1 protein, human
• Chitinase-3-Like Protein 1

Topics

• Biomarkers, Tumor (biosynthesis, blood)
• Carcinoma, Squamous Cell (pathology)
• Chitinase-3-Like Protein 1 (biosynthesis, blood)
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry (methods)
• Retrospective Studies
• Skin Neoplasms (pathology)