Abstract | BACKGROUND:
Angiopoietin-like 8 (ANGPTL8) a hepatic protein, is implicated by several studies with a role in promoting pancreatic β-cell proliferation and improving glucose tolerance. Although a matter of controversy, a growing number of reports support ANGPTL8's potential, yet unclear, role in type 2 diabetes (T2D). OBJECTIVES: To examine changes in fasting ANGPTL8 level in people with morbid obesity, with or without diabetes after laparoscopic sleeve gastrectomy (LSG) in a 1-year prospective study. SETTING: Dasman Diabetes Institute, government, and private hospitals, Kuwait. METHODS: Fasting serum ANGPTL8 was measured by enzyme-linked immunosorbent assay at baseline in participants with morbid obesity, 17 with diabetes and 23 without diabetes, and in healthy weight participants, 19 with and 15 without diabetes, during 1 year post-LSG in participants with morbid obesity. RESULTS: At baseline, people with T2D had higher ANGPTL8 level, (morbid obese, mean ± standard error of the mean; 1415 ± 196.4 pg/mL, and healthy weight, 2231 ± 328.1 pg/mL), compared with individuals without T2D (morbid obese, 876 ± 155.0 pg/mL, and healthy weight controls 868.9 ± 218.7 pg/mL). In participants with diabetes and morbid obesity, T2D remission occurred 15 days post-LSG, defined by a sustained reduced fasting blood glucose levels <6.9 mmol/L. In this group, the 1-year post-LSG measurement of ANGPTL8 showed unique biphasic changes, first a prominent elevation (day 60, 3336 ± 916.5 pg/mL, P < .01), followed by a gradual decrease to reach almost the baseline level (day 360, 1184 ± 119.3 pg/mL). CONCLUSION: Elevated baseline ANGPTL8 in participants with diabetes at baseline reflected a link to T2D. Interestingly, the unique biphasic pattern of change in fasting ANGPTL8 post-LSG, occurred only in people with diabetes, suggesting ANGPTL8's potential role in T2D remission.
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Authors | Eman Al-Shawaf, Ebaa Al-Ozairi, Fahad Al-Asfar, Shaima Al-Beloushi, Surbhi Kumari, Jaakko Tuomilehto, Hossein Arefanian |
Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
(Surg Obes Relat Dis)
Vol. 14
Issue 9
Pg. 1284-1294
(Sep 2018)
ISSN: 1878-7533 [Electronic] United States |
PMID | 30054251
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- ANGPTL8 protein, human
- Angiopoietin-Like Protein 8
- Angiopoietin-like Proteins
- Peptide Hormones
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Topics |
- Adult
- Angiopoietin-Like Protein 8
- Angiopoietin-like Proteins
(blood)
- Diabetes Mellitus, Type 2
(complications, epidemiology, physiopathology)
- Female
- Follow-Up Studies
- Gastrectomy
- Humans
- Laparoscopy
- Male
- Obesity, Morbid
(blood, complications, epidemiology, surgery)
- Peptide Hormones
(blood)
- Prospective Studies
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