Abstract | AIM: METHODS: RESULTS: Optimization resulted in a change in the method of selecting antibiotics for cesarean section, but there was no change in SSI incidence rate (0.74% vs 0.0%, P = 0.36). Optimization reduced the use of antibiotics and medical expenses of hysterectomy (median reduction of 50% and 78% for hysterectomy without or with lymphadenectomy, respectively). However, there was no change in outcome regarding SSI incidence (5.7% vs 0.0%, P = 0.11 and 7.8% vs 9.5%, P = 0.77, respectively). CONCLUSION: Appropriate use of antibiotics according to guidelines reduced antibiotic dose and medical expenses, but there was no change in outcome regarding SSI incidence rate. These findings suggested that implementation of dosing regimens according to the guidelines would be useful to reduce antibiotic medicine costs and prevent resistant bacteria and complications associated with antibiotics.
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Authors | Mikayo Toba, Mutsuko Moriwaki, Noriko Oshima, Yoshibumi Aiso, Mari Shima, Yoko Nukui, Satoshi Obayashi, Kiyohide Fushimi |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 44
Issue 9
Pg. 1800-1807
(Sep 2018)
ISSN: 1447-0756 [Electronic] Australia |
PMID | 30051538
(Publication Type: Journal Article)
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Copyright | © 2018 Japan Society of Obstetrics and Gynecology. |
Topics |
- Adult
- Aged
- Antibiotic Prophylaxis
(standards)
- Cesarean Section
(methods, standards)
- Female
- Humans
- Hysterectomy
(methods, standards)
- Japan
- Middle Aged
- Outcome Assessment, Health Care
- Practice Guidelines as Topic
(standards)
- Societies, Medical
(standards)
- Surgical Wound Infection
(prevention & control)
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