Abstract | BACKGROUND: METHODS: In this experiment, db/db mice were used as an animal model for type 2 diabetic nephropathy. The intervention ( QDTS granules and valsartan) started when the mice were 12 weeks old. C57BL/6 mice were used as normal control. The urine albumin excretion ratio (UAER) was measured by enzyme-linked immunosorbent assay (ELISA) before and after the intervention. The IRS-1, PI3K, Akt, and MAPK proteins expression and the phosphorylation levels were detected by western blot. RESULTS:
QDTS granules reduced the 24-h urinary albumin excretion rate (UAE) in db/db mice with type 2 DM and attenuated the pathological changes of the kidney. QDTS granules also increased the activation level of the PI3K/Akt signaling pathway and reduced insulin resistance. In addition, QDTS granules inhibited the activation of ERK and p38MAPK and decreased the phosphorylation ratio of Ser307/Tyr896 of IRS-1 in renal tissue. CONCLUSIONS:
|
Authors | Xue Gao, Hongfang Liu, Zhichao An, Qiying He |
Journal | Evidence-based complementary and alternative medicine : eCAM
(Evid Based Complement Alternat Med)
Vol. 2018
Pg. 2503849
( 2018)
ISSN: 1741-427X [Print] United States |
PMID | 30050584
(Publication Type: Journal Article)
|