Abstract | BACKGROUND: MATERIAL AND METHODS: 40 male Fischer344 rats were randomly assigned to 4 groups (n=10) - controls receiving only 1.5ml tap water per day by oral gavage for a total of 5 weeks (1) as well as rats receiving an additional daily normal etoricoxib dosage of 7.8mg/kg for 3d (2) and 7d/week (3) and a high dosage of 13.1mg/kg for 7d/week (4) with serum bioavailability assessed by liquid chromatography-mass spectrometry. After one week of premedication, the first upper left molars (M1) were moved orthodontically in anterior direction for 4 weeks using a closed NiTi coil spring (0.25N) and OTM as well as sagittal cranial growth were quantified cephalometrically by CBCT imaging at the start and end of OTM. RESULTS: OTM, quantified as anterior metric tipping of M1, was significantly inhibited by about 33% only in rats receiving high-dose etoricoxib 7d/week (p=0.046) with a respective, but insignificant tendency also detectable for the normal dosages, whereas sagittal cranial growth was by tendency slightly increased with rising etoricoxib dosages, reflected by corresponding steady-state serum concentrations, confirming etoricoxib bioavailability. CONCLUSIONS: An etoricoxib-induced clinically relevant deceleration of OTM is not to be expected at dosage regimens used in clinical practice to treat dental or orthodontic pain in contrast to a continuously administered high dosage. Due to its favorable side effect profile and higher analgesic efficiency regarding dental and orthodontic pain, etoricoxib should be a clinically valid alternative to the current standard orthodontic analgesic acetaminophen with its associated higher risk profile.
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Authors | Christian Kirschneck, Erika Calvano Küchler, Ulrich Wahlmann, Peter Proff, Agnes Schröder |
Journal | Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
(Ann Anat)
Vol. 220
Pg. 21-28
(Nov 2018)
ISSN: 1618-0402 [Electronic] Germany |
PMID | 30048759
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier GmbH. All rights reserved. |
Chemical References |
- Cyclooxygenase 2 Inhibitors
- Etoricoxib
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Topics |
- Animals
- Biological Availability
- Cone-Beam Computed Tomography
- Cyclooxygenase 2 Inhibitors
(adverse effects, pharmacokinetics, pharmacology)
- Etoricoxib
(adverse effects, pharmacokinetics, pharmacology)
- Male
- Molar
(diagnostic imaging, drug effects)
- Orthodontics
- Rats
- Rats, Inbred F344
- Skull
(diagnostic imaging, drug effects, growth & development)
- Tooth Movement Techniques
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