Abstract |
Myelodysplastic syndromes (MDS) in children and adolescents are a rare heterogeneous group of clonal stem cell disorders. Complete or partial loss of chromosome 7 constitutes the most common cytogenetic abnormality encountered in any type of childhood MDS, is associated with more advanced disease, and usually requires a timely allogeneic stem cell transplantation. This article provides insights into the current understanding of the genotype, phenotype, and clonal evolution patterns in pediatric MDS associated with loss of chromosome 7.
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Authors | Marcin W Wlodarski, Sushree S Sahoo, Charlotte M Niemeyer |
Journal | Hematology/oncology clinics of North America
(Hematol Oncol Clin North Am)
Vol. 32
Issue 4
Pg. 729-743
(Aug 2018)
ISSN: 1558-1977 [Electronic] United States |
PMID | 30047423
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2018 Elsevier Inc. All rights reserved. |
Topics |
- Adolescent
- Allografts
- Child
- Chromosome Deletion
- Chromosomes, Human, Pair 7
(genetics, metabolism)
- Clonal Evolution
- Hematopoietic Stem Cell Transplantation
- Humans
- Myelodysplastic Syndromes
(genetics, metabolism, pathology, therapy)
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