Abstract | AIM: METHODS: A total of 120 pregnant Egyptian women were included in the study. They were classified into two groups. Group A consisted of 50 women with neural tube defects in current pregnancy or with a history in previous pregnancies, and Group B consisted of 70 women with no history of neural tube defects in previous pregnancies or in the current pregnancy. All women were subjected to ultrasound anomaly scan and serum analysis of vitamin B12, homocysteine (Hcy), methyl malonic acid (MMA) and active vitamin B12 concentrations. Receiver operating characteristic curve analysis was used to determine the best cut-off values of vitamin B12. RESULTS: Serum levels of vitamin B12 were decreased in Neural tube defects (NTDs) cases compared to controls (2.736 vs 3.091 ng/mL; P = 0.0015), while Hcy and MMA concentrations were elevated (18.39 vs 13.95 μmol/L; P = 0.0008 and 263 vs 229.7 μmol/L; P = 0.003, respectively). Active vitamin B12 reduction was not statistically significant (96.8 vs 99.36 pmol/L; P = 0.8013). The optimal cut-off value of vitamin B12, 2.9 ng/mL, is the best threshold to expect neural tube defects, with a sensitivity of 60% and specificity of 74.29%. CONCLUSION:
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Authors | Sameh M Senousy, Mona K Farag, Amr S Gouda, Mohamed A El Noury, Ola A Dabbous, Khaled R Gaber |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 44
Issue 10
Pg. 1902-1908
(Oct 2018)
ISSN: 1447-0756 [Electronic] Australia |
PMID | 30043514
(Publication Type: Journal Article)
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Copyright | © 2018 Japan Society of Obstetrics and Gynecology. |
Chemical References |
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Topics |
- Adult
- Biomarkers
(blood)
- Egypt
- Female
- Humans
- Neural Tube Defects
(diagnostic imaging)
- Pregnancy
- Vitamin B 12
(blood)
- Young Adult
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