Abstract |
High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is widely used as a salvage therapy for relapsed or high-risk diffuse large B-cell lymphoma (DLBCL). To investigate the safety and efficacy of regimens including high-dose MCNU followed by ASCT for DLBCL, we analyzed the data from prospective multicenter trials. Twenty-nine patients were analyzed, and the median follow-up time for survival patients was 70 months. Fifteen patients received MCVC conditioning regimen, and fourteen patients received MEAM regimen. Major toxicities associated with these conditioning regimens included nausea (69%), anorexia (66%), febrile neutropenia (62%), diarrhea (59%), and mucositis (34%). One patient who developed severe sinusoidal obstructive syndrome and acute lung injury died without disease progression, and overall therapy-related mortality at 5 years was 3%. No patient developed therapy-related hematological malignancy. At 5 years, overall survival and progression-free survival in all patients were 82.8 and 58.2%, respectively. The 5-year OS in patients treated by the MCVC and MEAM regimens were 73.3 and 92.9%, respectively. These results suggest that regimens including high-dose MCNU followed by ASCT are feasible and effective for the treatment of relapsed or high-risk DLBCL. Further investigation is needed to evaluate of these regimens.
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Authors | Yoshihiro Kameoka, Tomoaki Akagi, Kazunori Murai, Hideyoshi Noji, Yuichi Kato, Osamu Sasaki, Shigeki Ito, Kenichi Ishizawa, Yoji Ishida, Ryo Ichinohasama, Hideo Harigae, Naoto Takahashi |
Journal | International journal of hematology
(Int J Hematol)
Vol. 108
Issue 5
Pg. 510-515
(Nov 2018)
ISSN: 1865-3774 [Electronic] Japan |
PMID | 30043334
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study)
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Chemical References |
- Nitrosourea Compounds
- ranimustine
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Topics |
- Adult
- Autografts
- Disease-Free Survival
- Female
- Follow-Up Studies
- Humans
- Lymphoma, Large B-Cell, Diffuse
(mortality, therapy)
- Male
- Middle Aged
- Nitrosourea Compounds
(administration & dosage, adverse effects)
- Prospective Studies
- Stem Cell Transplantation
- Survival Rate
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