The declining antibody level of measles virus in China population, 2009-2015.

Abstract

BACKGROUND:

To eliminate measles, the coverage of more than 90% vaccine is required in China. Nonetheless, the measles incidence still reached to 3.88 per 100,000 in 2014, which is far more than the target of 1 per 1,000,000. Moreover, there is little national surveillance to measles antibody level indicating herd immunity status in China.

METHODS:

We detected the level of antibody to measles using commercially available indirect enzyme-linked immunosorbent IgG assays, and calculated the protection rate of population (PRP) to measles virus infection among health peoples in China.

RESULTS:

During the years 2009-2015, among the Chinese population aged 0-56, PRP was 94.7, 91.6, 91.6, 84.2, 82.1, 81.0, 75.4%, respectively. Among all age bands, the PRP is lowest among children less than 12-month-age, followed by people over 15 years old.

CONCLUSION:

Measles antibody level among healthy population has been declined since 2012, supplemented measles vaccination activity may be necessary to eliminate measles in China.

• Authors: Ying Hu, Peishan Lu, Xiuying Deng, Hongxiong Guo, Minghao Zhou
• Journal: BMC public health (BMC Public Health) Vol. 18 Issue 1 Pg. 906 (07 24 2018) ISSN: 1471-2458 [Electronic] England
• PMID: 30041607 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Measles Vaccine

Topics

• Adolescent
• Adult
• Antibodies, Viral (blood)
• Child
• Child, Preschool
• China (epidemiology)
• Enzyme-Linked Immunosorbent Assay (methods)
• Female
• Humans
• Immunity, Herd
• Incidence
• Infant
• Infant, Newborn
• Male
• Measles (blood, epidemiology, prevention & control)
• Measles Vaccine
• Measles virus (immunology)
• Middle Aged
• Population Health (statistics & numerical data)
• Population Surveillance
• Serologic Tests
• Vaccination
• Vaccination Coverage
• Young Adult