Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes.

Abstract

Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen species (ROS) and mediates photocarcinogenesis and photoaging. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct generated by UVB exposure. FICZ exhibits similar biological effects to UVB, including AHR ligation and ROS production. FICZ also acts as a potent photosensitizer for UVA and the production of ROS is synergistically augmented in the simultaneous presence of FICZ and UVA. In contrast, FICZ upregulates the expression of terminal differentiation molecules such as filaggrin and loricrin via AHR. In parallel with this, the administration of FICZ inhibits skin inflammation in a murine psoriasis and dermatitis model. In this article, we summarize the harmful and beneficial aspects of FICZ in skin pathology.

• Authors: Masutaka Furue, Hiroshi Uchi, Chikage Mitoma, Akiko Hashimoto-Hachiya, Yuka Tanaka, Takamichi Ito, Gaku Tsuji
• Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (G Ital Dermatol Venereol) Vol. 154 Issue 1 Pg. 37-41 (Feb 2019) ISSN: 1827-1820 [Electronic] Italy
• PMID: 30035475 (Publication Type: Journal Article, Review)

Chemical References

• 6-formylindolo(3,2-b)carbazole
• Carbazoles
• FLG protein, human
• Filaggrin Proteins
• Reactive Oxygen Species
• Receptors, Aryl Hydrocarbon
• Tryptophan

Topics

• Animals
• Carbazoles (metabolism, radiation effects)
• Cell Differentiation (radiation effects)
• Disease Models, Animal
• Filaggrin Proteins
• Humans
• Keratinocytes (cytology, radiation effects)
• Mice
• Oxidative Stress (physiology, radiation effects)
• Reactive Oxygen Species (radiation effects)
• Receptors, Aryl Hydrocarbon (radiation effects)
• Skin Diseases (etiology, pathology)
• Tryptophan (metabolism, radiation effects)
• Ultraviolet Rays (adverse effects)