Abstract | BACKGROUND: METHODS: RESULTS: No relevant differences were observed for the primary end point of cardiac power index at 24 hours (mild therapeutic hypothermia versus control: 0.41 [interquartile range, 0.31-0.52] versus 0.36 [interquartile range, 0.31-0.48] W/m2; P=0.50; median difference, -0.025 W/m2; 95% CI, -0.12 to 0.06). Similarly, all other hemodynamic measurements were not statistically different. Arterial lactate levels at 6, 8, and 10 hours were significantly higher in patients in the mild therapeutic hypothermia group with a slower decline ( P for interaction=0.03). There were no differences in 30-day mortality (60% versus 50%; hazard ratio, 1.27; 95% CI, 0.55-2.94; P=0.55). CONCLUSIONS: CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01890317.
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Authors | Georg Fuernau, Johannes Beck, Steffen Desch, Ingo Eitel, Christian Jung, Sandra Erbs, Norman Mangner, Philipp Lurz, Karl Fengler, Alexander Jobs, Reinhard Vonthein, Suzanne de Waha-Thiele, Marcus Sandri, Gerhard Schuler, Holger Thiele |
Journal | Circulation
(Circulation)
Vol. 139
Issue 4
Pg. 448-457
(01 22 2019)
ISSN: 1524-4539 [Electronic] United States |
PMID | 30026282
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Female
- Germany
- Hemodynamics
- Humans
- Hypothermia, Induced
(adverse effects, methods, mortality)
- Lactic Acid
(blood)
- Male
- Myocardial Infarction
(diagnosis, mortality, physiopathology, therapy)
- Percutaneous Coronary Intervention
(adverse effects, mortality)
- Prospective Studies
- Recovery of Function
- Shock, Cardiogenic
(diagnosis, mortality, physiopathology, therapy)
- Time Factors
- Treatment Outcome
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