Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge.

Abstract

The objective of this study was to compare the efficacy of a commercial porcine reproductive and respiratory syndrome (PRRS) subunit vaccine and a prototype PRRS II subunit vaccine against a highly pathogenic PRRS virus (HP-PRRSV) in pigs. Both vaccines were administered intramuscularly in 2 doses at 21 and 42 days of age, and the pigs were challenged intranasally with HP-PRRSV at 63 days of age. Pigs vaccinated with the prototype PRRS II subunit vaccine had significantly higher anti-PRRSV antibody titers, a greater number of interferon-γ-secreting cells, and a greater reduction in lung lesion scores compared to pigs vaccinated with the commercial PRRS subunit vaccine. Therefore, the commercial PRRS subunit and prototype PRRS II subunit vaccines are efficacious against HP-PRRSV.

• Authors: Do Tien Duy, Hanjin Kim, Jiwoon Jeong, Kee Hwan Park, Siyeon Yang, Taehwan Oh, Seeun Kim, Ikjae Kang, Chanhee Chae
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 80 Issue 9 Pg. 1463-1467 (Sep 26 2018) ISSN: 1347-7439 [Electronic] Japan
• PMID: 30022776 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Vaccines, Attenuated
• Vaccines, Subunit
• Viral Vaccines

Topics

• Animals
• Antibodies, Viral (blood)
• Porcine Reproductive and Respiratory Syndrome (prevention & control)
• Porcine respiratory and reproductive syndrome virus (immunology)
• Swine
• Vaccines, Attenuated
• Vaccines, Subunit
• Viral Vaccines (administration & dosage, immunology)