HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evaluation of Oritavancin Combinations with Rifampin, Gentamicin, or Linezolid against Prosthetic Joint Infection-Associated Methicillin-Resistant Staphylococcus aureus Biofilms by Time-Kill Assays.

Abstract
The antibiofilm activity of oritavancin in combination with rifampin, gentamicin, or linezolid was evaluated against 10 prosthetic joint infection (PJI)-related methicillin-resistant Staphylococcus aureus (MRSA) isolates by time-kill assays. Oritavancin combined with rifampin demonstrated statistically significant bacterial reductions compared with those of either antimicrobial alone for all 10 isolates (P ≤ 0.001), with synergy being observed for 80% of the isolates. Oritavancin and rifampin combination therapy may be an option for treating MRSA PJI.
AuthorsQun Yan, Melissa J Karau, Yash S Raval, Robin Patel
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 62 Issue 10 (10 2018) ISSN: 1098-6596 [Electronic] United States
PMID30012765 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2018 American Society for Microbiology.
Chemical References
  • Gentamicins
  • Lipoglycopeptides
  • Linezolid
  • oritavancin
  • Rifampin
Topics
  • Biofilms (drug effects)
  • Gentamicins (pharmacology)
  • Linezolid (pharmacology)
  • Lipoglycopeptides (pharmacology)
  • Methicillin-Resistant Staphylococcus aureus (drug effects)
  • Microbial Sensitivity Tests
  • Rifampin (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: