Histone deacetylase 11 inhibits interleukin 10 in B cells of subjects with allergic rhinitis.

Abstract

BACKGROUND:

The interleukin (IL)-10 expression in B cells plays an important role in immune tolerance. The regulation of IL-10 expression in B cells is not fully understood yet. Tumor necrosis factor (TNF) is increased in allergic rhinitis (AR) patients. This study tests a hypothesis that TNF enhances histone deacetylase (HDAC)11 expression to inhibit the expression of IL-10 in B cells of AR patients.

METHODS:

Peripheral B cells were collected from healthy persons and patients with AR. The B cells were analyzed by immune assay and molecular biological approaches for the expression of IL-10.

RESULTS:

The expression of HDAC11 was higher in B cells of patients with AR than that in healthy persons. The expression of IL-10 in B cells was lower in AR patients than that in healthy subjects. The levels of HDAC11 in B cells were negatively correlated with the levels of IL-10. Exposure of B cells to TNF in the culture inhibited the expression of IL-10, in which HDAC11 played a critical role in the interference with the Il10 gene transcription. Inhibition of HDAC11 restored the IL-10 expression in B cells from AR patients and attenuated the experimental AR.

CONCLUSION:

TNF can suppress the expression of IL-10 in B cells via enhancing the expression of HDAC11. Inhibition of HDAC11 restores the IL-10 expression in B cells of AR subjects. HDAC11 may be a novel target for the treatment of AR.

• Authors: Jian-Bo Shao, Xiang-Qian Luo, Yong-Jin Wu, Mao-Gang Li, Jing-Yi Hong, Li-Hua Mo, Zhi-Gang Liu, Hua-Bin Li, Da-Bo Liu, Ping-Chang Yang
• Journal: International forum of allergy & rhinology (Int Forum Allergy Rhinol) Vol. 8 Issue 11 Pg. 1274-1283 (11 2018) ISSN: 2042-6984 [Electronic] United States
• PMID: 30007011 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 ARS-AAOA, LLC.

Chemical References

• Cytokines
• Immunoglobulin E
• HDAC11 protein, human
• Histone Deacetylases

Topics

• Adult
• Animals
• B-Lymphocytes (immunology)
• Cells, Cultured
• Cytokines (blood)
• Female
• Histone Deacetylases (immunology)
• Humans
• Immunoglobulin E (blood)
• Male
• Mice, Inbred BALB C
• Rhinitis, Allergic (immunology)
• Spleen (immunology)
• Young Adult