Abstract | BACKGROUND: RESULTS: 5hmC was decreased in bladder cancer samples and was related to patient overall survival. Genome-wide mapping of 5hmC in tumor tissues and vitamin C-treated bladder cancer cells revealed that 5hmC loss was enriched in cancer-related genes and that vitamin C treatment increased 5hmC levels correspondingly. Vitamin C treatment shifted the transcriptome and inhibited the malignant phenotypes associated with bladder cancer cells in both in vitro cell lines and in vivo xenografts. CONCLUSIONS:
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Authors | Ding Peng, Guangzhe Ge, Yanqing Gong, Yonghao Zhan, Shiming He, Bao Guan, Yifan Li, Ziying Xu, Han Hao, Zhisong He, Gengyan Xiong, Cuijian Zhang, Yue Shi, Yuanyuan Zhou, Weimin Ci, Xuesong Li, Liqun Zhou |
Journal | Clinical epigenetics
(Clin Epigenetics)
Vol. 10
Issue 1
Pg. 94
(07 13 2018)
ISSN: 1868-7083 [Electronic] Germany |
PMID | 30005692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 5-hydroxymethylcytosine
- 5-Methylcytosine
- Ascorbic Acid
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Topics |
- 5-Methylcytosine
(analogs & derivatives, metabolism)
- Aged
- Animals
- Ascorbic Acid
(administration & dosage, pharmacology)
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Female
- Gene Expression Regulation, Neoplastic
(drug effects)
- Gene Regulatory Networks
(drug effects)
- Humans
- Male
- Mice
- Middle Aged
- Prognosis
- Sequence Analysis, DNA
- Sequence Analysis, RNA
- Survival Analysis
- Urinary Bladder Neoplasms
(drug therapy, metabolism)
- Xenograft Model Antitumor Assays
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