Abstract | BACKGROUND: METHODS: Cohort study investigating 3-year heart allograft survival according to spontaneous core body temperature (CBT) assessed on the day of organ procurement. The study is nested in the database of the randomized trial of donor pretreatment with low-dose dopamine (ClinicalTrials.gov identifier: NCT000115115). RESULTS: Ninety-nine heart transplant recipients who had received a cardiac allograft from a multiorgan donor enrolled in the dopamine trial were grouped by tertiles of the donor's CBT assessed by a mere temperature reading 4 to 20 hours before procurement (lowest, 32.0-36.2°C; middle, 36.3-36.8°C; highest, 36.9-38.8°C). Baseline characteristics considering demographics of donors and recipients, concomitant donor treatments, donor hemodynamic, and respiratory parameters as well as underlying cardiac diseases in recipients, pretransplant hemodynamic assessments, including pretransplant inotropic/mechanical support, urgency, and waiting time were similar. A lower CBT was associated with inferior heart allograft survival (hazard ratio, 0.53; 95% confidence interval, 0.31-0.93, per tertile; P = 0.02, and hazard ratio, 0.68; 95% confidence interval, 0.50-0.93°C; P = 0.02) when CBT was included as continuous explanatory variable in the Cox regression analysis. CONCLUSIONS:
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Authors | Peter Schnuelle, Urs Benck, Bernhard K Krämer, Benito A Yard, Andreas Zuckermann, Florian Wagner, Gabor Szabo, Martin Borggrefe, Matthias Karck, Jan Gummert |
Journal | Transplantation
(Transplantation)
Vol. 102
Issue 11
Pg. 1891-1900
(Nov 2018)
ISSN: 1534-6080 [Electronic] United States |
PMID | 29994980
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Body Temperature
- Brain Death
(physiopathology)
- Databases, Factual
- Female
- Heart Transplantation
(adverse effects, methods)
- Humans
- Male
- Middle Aged
- Multicenter Studies as Topic
- Randomized Controlled Trials as Topic
- Risk Factors
- Time Factors
- Tissue Donors
- Tissue and Organ Harvesting
(adverse effects, methods)
- Treatment Outcome
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