90 Y-ibritumomab-tiuxetan as a therapeutic alternative for follicular lymphoma (FL): A single-center experience.

Abstract

BACKGROUND:

Follicular lymphoma (FL) is the most frequent indolent lymphoma subtype in adults. Maintenance therapy with rituximab is frequently applied to FL patients with complete or partial response following initial chemoimmunotherapy. However, radioimmunotherapy with 90 Y-ibritumomab-tiuxetan represents a therapeutic alternative.

METHODS:

To compare the clinical and the prognostic impact of both therapies, a study collective of n = 56 patients diagnosed with indolent B-cell lymphoma was retrospectively investigated. The study collective was subdivided into two groups: n = 36 patients treated with rituximab maintenance therapy vs n = 20 patients treated with 90 Y-ibritumomab-tiuxetan.

RESULTS:

No prognostic differences for performance status, FLIPI score, gender, or B-symptoms were found for 90 Y-ibritumomab-tiuxetan or rituximab maintenance therapy. Overall survival rates and progression-free survival did not differ between both maintenance therapies.

CONCLUSION:

Our retrospective single-center analysis of two patient groups without major differences in prognostic parameters revealed similar outcome with two different maintenance therapies. Hence, 90 Y-ibritumomab-tiuxetan therapy might offer a valuable alternative treatment option for FL patients with partial response. However, large prospective trials are needed to confirm the reported findings.

• Authors: Eva U Spukti, Lars Henning Schmidt, Arik Schulze, Christoph Schliemann, Dennis Görlich, Eva Wardelmann, Wolfgang Hartmann, Georg Lenz, Wolfgang E Berdel, Andrea Kerkhoff
• Journal: European journal of haematology (Eur J Haematol) Vol. 101 Issue 4 Pg. 514-521 (Oct 2018) ISSN: 1600-0609 [Electronic] England
• PMID: 29993147 (Publication Type: Journal Article)
• Copyright: © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Antibodies, Monoclonal
• Immunoconjugates
• Yttrium Radioisotopes
• ibritumomab tiuxetan

Topics

• Adult
• Aged
• Antibodies, Monoclonal (administration & dosage, adverse effects, therapeutic use)
• Combined Modality Therapy
• Female
• Humans
• Immunoconjugates (administration & dosage, adverse effects, therapeutic use)
• Lymphoma, Follicular (mortality, pathology, therapy)
• Maintenance Chemotherapy
• Male
• Middle Aged
• Multimodal Imaging
• Neoplasm Staging
• Survival Analysis
• Treatment Outcome
• Yttrium Radioisotopes (therapeutic use)