Abstract | BACKGROUND: METHODS: After ethics board approval, this cross-sectional study was conducted at two universities with 44 patients (mean ± standard deviation age 12.6 ± 4.9, range 2-24 years) with CKD stage of 1-5. Laboratory parameters studied were Cystatin C (CysC), CysC estimated glomerular filtration rate (eGFR) (calculated from the Filler formula), sd- LDL, g- LDL and albumin. Lipid samples were measured for sd- LDL and g- LDL using ELISA. Non-linear correlation analysis was performed to determine the relationship between g- LDL, sd- LDL and eGFR. Clinical Trials Registration is at clinicaltrials.gov, NCT02126293, https://clinicaltrials.gov/ct2/show/NCT02126293. RESULTS:
Triglycerides, but not total cholesterol and calculated LDL, were associated with CKD stages (ANOVA P = 0.0091). As in adults, sd- LDL was significantly associated with CKD stages (ANOVA P = 0.0133), CysC eGFR (r = -0.6495, P < 0.00001), and body mass index (r = -0.3895, P = 0.0189), but not with age. By contrast, there was no significant correlation between g- LDL and CKD stages or CysC eGFR (P = 0.9678). CONCLUSIONS: Our study demonstrates that only triglycerides and sd- LDL were associated with CKD stages in this young cohort without confounding Framingham-type CVD risk factors. While larger studies are needed, this study suggests that lowering sd- LDL levels may be a potential target to ameliorate the long-term CVD risks in paediatric CKD patients.
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Authors | Guido Filler, Sepideh Taheri, Christopher McIntyre, Connor Smith, Lakshmimathy Subramanian, Gerhard Fusch, Christoph Fusch |
Journal | Clinical kidney journal
(Clin Kidney J)
Vol. 11
Issue 3
Pg. 383-388
(Jun 2018)
ISSN: 2048-8505 [Print] England |
PMID | 29992019
(Publication Type: Journal Article)
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