Drug transporters and anthracycline-induced cardiotoxicity.

Abstract

The solute carrier superfamily comprises of uptake transporters that can contribute to the absorption and elimination of a broad array of clinically important drugs. Recent studies have suggested that the tissue-specific expression of these transporters may have important consequences for an individual's susceptibility to drug-induced organ damage or to drug-drug interactions. Polymorphic variants have been identified in genes encoded by this family, and some of these have been associated with functional changes in transport function and response to anthracycline-induced toxicity and efficacy. Here, we review recent advances in the role solute carrier transporters play in anthracycline-induced cardiotoxicity, highlight potential implications of genetic variants that may contribute to drug response and discuss novel technologies to study mechanisms of anthracycline transport.

• Authors: Kevin M Huang, Shuiying Hu, Alex Sparreboom
• Journal: Pharmacogenomics (Pharmacogenomics) Vol. 19 Issue 11 Pg. 883-888 (07 01 2018) ISSN: 1744-8042 [Electronic] England
• PMID: 29991332 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anthracyclines
• Membrane Transport Proteins

Topics

• Anthracyclines (adverse effects)
• Biological Transport (genetics)
• Cardiotoxicity (genetics)
• Drug Interactions (genetics)
• Genetic Variation (genetics)
• Humans
• Membrane Transport Proteins (genetics)