Abstract | OBJECTIVES: METHODS: We performed a cross-sectional study including 11 261 Chinese adults. NAFLD was diagnosed based on the Chinese Guidelines for the diagnosis and treatment of fatty liver diseases and an alcohol intake of <70 g/week in women and <140 g/week in men, and serum immunoglobulin (Ig) levels were determined using immune nephelometry. Multiple logistic regression analysis was done to assess relationships between concentrations of serum immunoglobulins and NAFLD. RESULTS: Of the 11 261 adults recruited from January 2010 to December 2015, the prevalence of NAFLD was 40.8% (n = 4598). The geometric mean levels of IgG, IgM, IgE and IgA were 1177.49 mg/dL (95% confidence interval [CI] 1173.07-1181.93), 93.56 mg/dL (95% CI 92.70-94.42), 30.70 IU/mL (95% CI 29.92-31.49) and 216.64 mg/dL (95% CI 214.95-218.34), respectively. Compared with the lowest quintile, the multivariable adjusted odds ratio (95% CI) of NAFLD for the highest quintile of IgG, IgM, IgE, and IgA were 0.78 (0.66-0.92), 0.71 (0.60-0.84), 0.98 (0.84-1.15) and 1.41 (1.21-1.66), respectively. CONCLUSION: Increased IgA and decreased IgG and IgM levels are independently associated with NAFLD prevalence. Further research is needed to explore the causal association between serum immunoglobulins and NAFLD.
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Authors | Shao Mei Sun, Yan Yan Wang, Qing Zhang, Li Liu, Ge Meng, Zhan Xin Yao, Hong Mei Wu, Yang Xia, Xue Bao, Ye Qing Gu, Hong Lei Wang, Hong Bin Shi, Hai Yan Xu, Xing Wang, Ming Zhou, Huan Li Jiao, Qi Yu Jia, Bang Mao Wang, Kai Jun Niu |
Journal | Journal of digestive diseases
(J Dig Dis)
Vol. 19
Issue 8
Pg. 498-507
(Aug 2018)
ISSN: 1751-2980 [Electronic] Australia |
PMID | 29989347
(Publication Type: Journal Article)
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Copyright | © 2018 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Immunoglobulins
- Immunoglobulin E
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Topics |
- Adult
- Case-Control Studies
- China
(epidemiology)
- Cross-Sectional Studies
- Female
- Humans
- Immunoglobulin A
(blood)
- Immunoglobulin E
(blood)
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Immunoglobulins
(blood)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(blood, diagnostic imaging, epidemiology)
- Prevalence
- Prospective Studies
- Ultrasonography
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