Abstract | BACKGROUND:
Liuweiwuling tablets (LWWL) are an herbal product that exerts remarkable effects on liver protection and aminotransferase levels, and they have been approved by the Chinese State Food and Drug Administration (CFDA). Clinical studies have found that LWWL can inhibit collagen production and reduce the levels of liver fibrosis markers in the serum. Thus, LWWL is expected to have beneficial effects in the treatment of liver fibrosis. The purpose of this study was to evaluate the pharmacological effects of LWWL. METHODS: RESULTS: LWWL significantly reversed histological fibrosis and liver injury, reduced the hydroxyproline content in liver tissue, and decreased α-SMA and collagen I expression. LWWL also suppressed hepatic stellate cell (HSC) activation by reducing the expression of the profibrogenic factors TGF-β1 and PDGF. The expression levels of TIMP1 and TIMP2, which regulate extracellular matrix (ECM) degradation, were decreased after CCl4 injury in LWWL-treated rats. CONCLUSIONS: These data suggest that LWWL may serve as a promising therapeutic agent to reduce fibrogenesis.
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Authors | Huimin Liu, Zhenfang Zhang, Huangwanyin Hu, Congen Zhang, Ming Niu, Ruishen Li, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 18
Issue 1
Pg. 212
(Jul 09 2018)
ISSN: 1472-6882 [Electronic] England |
PMID | 29986685
(Publication Type: Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Tablets
- Tissue Inhibitor of Metalloproteinase-1
- Transforming Growth Factor beta1
- liuweiwuling
- Tissue Inhibitor of Metalloproteinase-2
- Carbon Tetrachloride
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Topics |
- Animals
- Carbon Tetrachloride
(adverse effects)
- Drugs, Chinese Herbal
(administration & dosage)
- Humans
- Liver Cirrhosis
(drug therapy, genetics, metabolism)
- Male
- Rats
- Rats, Sprague-Dawley
- Tablets
(administration & dosage)
- Tissue Inhibitor of Metalloproteinase-1
(genetics, metabolism)
- Tissue Inhibitor of Metalloproteinase-2
(genetics, metabolism)
- Transforming Growth Factor beta1
(genetics, metabolism)
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