Abstract | BACKGROUND: METHODS: We conducted a prospective study of 92 patients with PP undergoing an ACTH stimulation test. We tested the association of basal clinical and biochemical parameters with NCCAH diagnosis. Patients were suspected to have NCCAH if their stimulated 17OHP plasma levels were >10 ng/mL. In these patients, the diagnosis was confirmed by genetic test. RESULTS: Seven (7.6%) patients resulted having NCCAH. The best basal biochemical predictor for NCCAH was 17OHP level >2 ng/mL. In fact, a basal 17OHP level >2 ng/mL had 100% (95% confidence interval (CI), 59.04-100) sensitivity and 93% (95% CI, 85.3-97.37) specificity. The area under the receiver-operating characteristic curve for 17OHP was 0.99 (95% CI, 0.98-1.007). CONCLUSIONS: Basal 17OHP cut-off of 2 ng/mL was very effective in predicting NCCAH among our patients with PP. Assay-specific cut-off would probably be the best strategy to avoid unnecessary ACTH test.
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Authors | Anna Grandone, Pierluigi Marzuillo, Caterina Luongo, Roberto Toraldo, Michela Mariani, Emanuele Miraglia Del Giudice, Laura Perrone |
Journal | Pediatric research
(Pediatr Res)
Vol. 84
Issue 4
Pg. 533-536
(10 2018)
ISSN: 1530-0447 [Electronic] United States |
PMID | 29976972
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- 17-alpha-Hydroxyprogesterone
- Adrenocorticotropic Hormone
- CYP21A2 protein, human
- Steroid 21-Hydroxylase
- Hydrocortisone
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Topics |
- 17-alpha-Hydroxyprogesterone
(blood)
- Adrenal Hyperplasia, Congenital
(blood, diagnosis)
- Adrenocorticotropic Hormone
(blood)
- Child
- Child, Preschool
- Female
- Genetic Testing
- Hair
(growth & development)
- Humans
- Hydrocortisone
(blood)
- Male
- Predictive Value of Tests
- Prospective Studies
- Puberty, Precocious
(blood, diagnosis)
- ROC Curve
- Reference Values
- Sensitivity and Specificity
- Steroid 21-Hydroxylase
(genetics)
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