Propolis emulgel: a natural remedy for burn and wound.

Abstract

OBJECTIVES:

To develop an alternative medicine, propolis, in emulgel formulation for burn and wound treatment.

METHODS:

The effect of two independent variables: emulsifying agent concentration and oil concentration on the cumulative amount of propolis release (dependent variable) from liquid paraffin and isopropyl palmitate emulgels was investigated. Eight formulations were prepared and evaluated for physical appearance, pH, propolis content, viscosity, and in vitro propolis release. The release results were fitted into different kinetic equations and analyzed using contour plot, interaction surface plot and one-way ANOVA. The selected emulgel formulation was investigated for its wound and burn healing activity in rats.

RESULTS:

All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, and pH value. The concentration of emulsifying agent had more pronounced effect on propolis release than oil concentration. Formulations F1-F6 showed "anomalous" drug release, while Formulations F7 and F8 showed zero-order kinetic.

CONCLUSION:

The formulation F7 with 5% isopropyl palmitate, 5% emulsifier mixture, 1% hydroxyl propyl methyl cellulose, 1% oleic acid, and 10% propylene glycol is a promising formula for better management of wound and burn.

• Authors: Gehan Fathy Balata, HananAbd El-Moneom Shamardl, Hanan Mohamed Abd Elmoneim, Afnan Abdullah Hakami, Maeen Abdulaziz Almodhwahi
• Journal: Drug development and industrial pharmacy (Drug Dev Ind Pharm) Vol. 44 Issue 11 Pg. 1797-1808 (Nov 2018) ISSN: 1520-5762 [Electronic] England
• PMID: 29973098 (Publication Type: Journal Article)

Chemical References

• Emulsions
• Gels
• Propolis

Topics

• Animals
• Burns (drug therapy)
• Drug Compounding
• Drug Liberation
• Emulsions
• Gels
• Hydrogen-Ion Concentration
• Propolis (administration & dosage, chemistry, pharmacology)
• Rats
• Rats, Wistar
• Viscosity
• Wound Healing (drug effects)