Abstract | BACKGROUND: METHODS: Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n = 10), and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP-9, IL-17, and CD105 (neoformed microvessels). Semiquantitative (IL-17) and quantitative (CD66b, IL-17, MMP-9, and CD105) analyses were performed. Clinical information (TNM stage, metastasis, recurrence, and survival) and tumor histological grade were also obtained. RESULTS: Positivity for TAN, MMP-9, IL-17, and CD105 was higher in OSCC than in the negative control (P < 0.05) and oral leukoplakia, but similar to the positive inflammatory control. Coincident high counts of inflammatory markers (CD66b, MMP-9, IL-17, and CD105) were associated with lymph node metastasis of OSCC. Associations between high numbers of neoformed microvessels and advanced clinical stage and a higher degree of malignancy were also demonstrated. CONCLUSIONS: Combined positivity for TAN, MMP-9, IL-17, and CD105 appears to be associated with the metastasis-prone phenotype of OSCC.
|
Authors | Ricardo Natã Fonseca Silva, Laís Bueno Dallarmi, Ana Karoline Carvalho Araujo, Rita Cassia Gonçalves Alencar, Elismauro Francisco Mendonça, Tarcília Aparecida Silva, Aline Carvalho Batista, Nadia Lago Costa |
Journal | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
(J Oral Pathol Med)
Vol. 47
Issue 9
Pg. 856-863
(Oct 2018)
ISSN: 1600-0714 [Electronic] Denmark |
PMID | 29964301
(Publication Type: Journal Article)
|
Copyright | © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antigens, CD
- Biomarkers, Tumor
- CEACAM8 protein, human
- Cell Adhesion Molecules
- ENG protein, human
- Endoglin
- GPI-Linked Proteins
- Interleukin-17
- MMP9 protein, human
- Matrix Metalloproteinase 9
|
Topics |
- Adult
- Antigens, CD
(analysis)
- Biomarkers, Tumor
(analysis)
- Carcinoma, Squamous Cell
(blood, blood supply, diagnosis)
- Cell Adhesion Molecules
(analysis)
- Endoglin
(analysis)
- Female
- GPI-Linked Proteins
(analysis)
- Humans
- Immunohistochemistry
(methods)
- Interleukin-17
(analysis)
- Male
- Matrix Metalloproteinase 9
(analysis)
- Middle Aged
- Mouth Neoplasms
(blood supply, diagnosis)
- Neovascularization, Pathologic
- Neutrophils
(pathology)
- Prognosis
|