Stress Granule Formation is One of the Early Antiviral Mechanisms for Host Cells Against Coxsackievirus B Infection.

Abstract	Stress granules (SGs) are intracellular granules formed when cellular translation is blocked and have been reported to be involved in a variety of viral infections. Our previous studies revealed that SGs are involved in the coxsackievirus B (CVB) infection process, but the role of SGs in CVB infection has not been fully explored. In this study, we found that CVB type 3 (CVB3) could induce SG formation in the early phase of infection. Results showed that levels of CVB3 RNA and protein were significantly inhibited during the early stage of CVB3 infection by the elevated formation of SGs, while viral RNA and protein synthesis were significantly promoted when SG formation was blocked. Our findings suggest that SG formation is one of the early antiviral mechanisms for host cells against CVB infection.
Authors	Xia Zhai, Shuo Wu, Lexun Lin, Tianying Wang, Xiaoyan Zhong, Yang Chen, Weizhen Xu, Lei Tong, Yan Wang, Wenran Zhao, Zhaohua Zhong
Journal	Virologica Sinica (Virol Sin) Vol. 33 Issue 4 Pg. 314-322 (Aug 2018) ISSN: 1995-820X [Electronic] Netherlands
PMID	29959686 (Publication Type: Journal Article)
Chemical References	Antiviral Agents Capsid Proteins ELAV-Like Protein 1 ELAVL1 protein, human Eukaryotic Initiation Factor-2 Poly-ADP-Ribose Binding Proteins RNA Recognition Motif Proteins RNA, Viral T-Cell Intracellular Antigen-1 TIA1 protein, human VP1 protein, enterovirus B DNA Helicases G3BP1 protein, human RNA Helicases
Topics	Antiviral Agents (metabolism) Capsid Proteins (biosynthesis) Coxsackievirus Infections (virology) Cytoplasmic Granules (metabolism) DNA Helicases (genetics) ELAV-Like Protein 1 (genetics, metabolism) Enterovirus B, Human (physiology) Eukaryotic Initiation Factor-2 (metabolism) Gene Knockdown Techniques HeLa Cells Host-Pathogen Interactions Humans Phosphorylation Poly-ADP-Ribose Binding Proteins (genetics) RNA Helicases (genetics) RNA Recognition Motif Proteins (genetics) RNA, Viral (biosynthesis) Stress, Physiological T-Cell Intracellular Antigen-1 (genetics, metabolism) Virus Replication

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!