Preptin is a new predictor of coronary artery calcification.

Abstract

BACKGROUND:

We aimed to assess whether an elevated preptin level is associated with coronary artery calcification (CAC).

METHODS:

Two hundred and twenty participants with suspected cardiovascular disease were recruited. CAC was measured using 320-row-detector dynamic volume CT, and the patients were divided into 2 groups: the non-CAC group (with an Agatston score = 0) and the CAC group (with an Agatston score > 0).

RESULTS:

The serum preptin level was significantly elevated in the CAC group compared with the non-CAC group. In logistic regression analysis, preptin, as well as age, gender, hypertension history and history of β-blocker use, were independent predictors of a positive CAC score. The highest preptin quintile of patients had a higher CAC level compared with other quintiles. Binary logistic regression analyses showed that the highest preptin quintile had a 2.9-time increased odds ratio of an elevated CAC level than the other 4 quintile patients.

CONCLUSIONS:

This study demonstrated that serum preptin was associated with coronary artery calcification.

• Authors: Bo Li, Yuhua Li, Tongtong Zhang, Litao Song, Chengbin Lei, Yan Zhao, Bing He, Yunhe Zhao, Bo Yin, Xiaodong Jin, Tao Li
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 485 Pg. 133-138 (Oct 2018) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 29958889 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Minerals
• Peptide Fragments
• preptin
• Insulin-Like Growth Factor II

Topics

• Bone and Bones (metabolism)
• Coronary Artery Disease (blood)
• Female
• Humans
• Insulin-Like Growth Factor II
• Male
• Middle Aged
• Minerals (metabolism)
• Peptide Fragments (blood)
• Predictive Value of Tests
• Vascular Calcification (blood)