Abstract | PURPOSE: RCTs in septic shock negative for mortality may show organ dysfunction benefits. We hypothesized that RCTs in septic shock show significant differences between treatment groups in organ support despite no mortality differences. METHODS: RESULTS: CONCLUSIONS: Differences between treatment groups in organ dysfunction in RCTs in septic shock occur despite lack of mortality differences depending on calculation method. If standardized and validated further, DAF could become the primary endpoint of RCTs in septic shock.
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Authors | James A Russell, Terry Lee, Joel Singer, Daniel De Backer, Djillali Annane |
Journal | Journal of critical care
(J Crit Care)
Vol. 47
Pg. 333-337
(10 2018)
ISSN: 1557-8615 [Electronic] United States |
PMID | 29958734
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier Inc. All rights reserved. |
Chemical References |
- AVP protein, human
- Neurophysins
- Protein Precursors
- Vasoconstrictor Agents
- Vasopressins
- Dobutamine
- Dopamine
- Norepinephrine
- Epinephrine
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Topics |
- Clinical Trials as Topic
- Dobutamine
(therapeutic use)
- Dopamine
(therapeutic use)
- Epinephrine
(therapeutic use)
- Humans
- Neurophysins
(metabolism)
- Norepinephrine
(therapeutic use)
- Protein Precursors
(metabolism)
- Randomized Controlled Trials as Topic
- Shock
(mortality)
- Shock, Septic
(drug therapy, mortality)
- Time Factors
- Treatment Outcome
- Vasoconstrictor Agents
(therapeutic use)
- Vasopressins
(metabolism, therapeutic use)
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