The intrathecal polyspecific antiviral immune response (MRZ reaction): A potential cerebrospinal fluid marker for multiple sclerosis diagnosis.

Abstract

We tested the performance of MRZ-reaction, an intrathecal humoral immune response against-Measles (M), Rubella (R) and Varicella Zoster (Z) viruses, in multiple sclerosis (MS) diagnosis. The MRZ-reaction was significantly more positive in MS than in non-MS group with a specificity of 91.9%. In MS group, the RZ-profile was the most prevalent and the R-specific antibody-index was correlated to the number of oligoclonal bands (OCB) in CSF. Interestingly, the MRZ-reaction was detected in 53% of OCB-negative-MS patients. The MRZ-reaction seems to be a relevant CSF diagnostic marker of MS disease. The likely relation between its positivity and the vaccination status deserves to be investigated.

• Authors: Sawsan Feki, Saba Gargouri, Sabrina Mejdoub, Mariem Dammak, Hend Hachicha, Olfa Hadiji, Lamia Feki, Adnen Hammami, Chokri Mhiri, Hela Karray, Hatem Masmoudi
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 321 Pg. 66-71 (08 15 2018) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 29957390 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers

Topics

• Adolescent
• Adult
• Aged
• Biomarkers (cerebrospinal fluid)
• Female
• Herpesvirus 3, Human (isolation & purification, metabolism)
• Humans
• Immunity, Humoral (physiology)
• Male
• Measles virus (isolation & purification, metabolism)
• Middle Aged
• Multiple Sclerosis (cerebrospinal fluid, diagnosis)
• Rubella virus (isolation & purification, metabolism)
• Young Adult