Relationship of para- and perirenal fat and epicardial fat with metabolic parameters in overweight and obese subjects.

Abstract

BACKGROUND:

The accumulation of visceral body fat, has been shown to be associated with higher risk of metabolic and cardiovascular disease. This study was addressed to examine whether para- and perirenal fat thickness and epicardial fat thickness were correlated with anthropometric- and cardiometabolic risk factors.

METHODS:

A cohort of 102 uncomplicated overweight and obese patients was examined. BMI, waist circumference, blood pressure, fasting insulin, glucose, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol serum levels, and insulin resistance (assessed by HOMAIR) were measured. Para- and perirenal fat thickness (PUFT) and epicardial fat thickness (EUFT) were measured by ultrasounds.

RESULTS:

PUFT was positively correlated with BMI (p < 0.001), waist circumference (p < 0.001), insulin (p < 0.001), HOMAIR (p < 0.001), triglycerides (p < 0.05), systolic (p < 0.05) and diastolic (p < 0.05) blood pressure, and negatively correlated with HDL-cholesterol (p < 0.01). EUFT was positively associated with age (p < 0.01), BMI (p < 0.001), waist circumference (p < 0.001), systolic (p < 0.01) and diastolic (p < 0.001) blood pressure, and LDL-cholesterol (p < 0.05). A multivariate analysis by multiple linear regression was performed, and the final model showed a direct association of waist circumference with both PUFT and EUFT, a correlation of PUFT with HOMAIR (positive) and HDL-cholesterol (negative), and a direct association of EUFT (both long axis and short axis) with LDL-cholesterol. All these correlations were independent of other anthropometric, metabolic and hemodynamic parameters.

CONCLUSIONS:

This study shows that accumulation of central fat in apparently healthy overweight and obese subjects is associated to a simultaneous increase of pararenal, perirenal and epicardial fat. Moreover, it shows that only para- and perirenal fat is independently associated to insulin resistance and lower HDL-cholesterol, and only epicardial fat is independently associated to higher LDL cholesterol. Level of evidence Level V, cross-sectional descriptive study.

• Authors: Carlo Manno, Nicla Campobasso, Adele Nardecchia, Vincenzo Triggiani, Roberta Zupo, Loreto Gesualdo, Franco Silvestris, Giovanni De Pergola
• Journal: Eating and weight disorders : EWD (Eat Weight Disord) Vol. 24 Issue 1 Pg. 67-72 (Feb 2019) ISSN: 1590-1262 [Electronic] Germany
• PMID: 29956099 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Lipids

Topics

• Adolescent
• Adult
• Blood Glucose
• Blood Pressure
• Body Mass Index
• Cross-Sectional Studies
• Female
• Humans
• Insulin Resistance (physiology)
• Intra-Abdominal Fat (diagnostic imaging)
• Lipids (blood)
• Male
• Middle Aged
• Obesity (diagnostic imaging, metabolism)
• Overweight (diagnostic imaging, metabolism)
• Waist Circumference (physiology)
• Young Adult