Noninfectious
fevers are common early after T cell-replete HLA haploidentical (haplo) peripheral blood transplants and have been associated with
cytokine release syndrome and overall mortality. However, less is known regarding the incidence and associations of early
fever after
bone marrow transplantation (BMT) with post-transplant
cyclophosphamide (PTCy). We hypothesized that early
fever would be associated with myeloablative conditioning (MAC), because of its relative increase in tissue damage augmenting antigen presentation and class II HLA-mismatching because of recognition of antigen-presenting cells by CD4+ T cells. In 672 recipients of MAC HLA-matched related donor (MRD) (n = 183), MAC HLA-matched unrelated donor (MUD) (n = 115), MAC haplo (n = 79), or nonmyeloablative (NMA) haplo (n = 295) T cell-replete BMT with PTCy, we retrospectively analyzed early noninfectious
fever defined as temperature of ≥38.3°C once or ≥38.0°C twice or more on days 1 to 6.
Fever occurred in 13% after MAC MRD, 23% after MAC MUD, 44% after NMA haplo, and 84% after MAC haplo BMT (P < .0001). Survival outcomes did not differ between patients with and without early
fever. In NMA haplo BMT, mismatch in the graft-versus-host direction at
HLA-DRB1 or -DPB1 (but not
HLA-A, -B, -Cw, or -DQB1) was associated with early
fever compared with no mismatches at these loci (P < .0001 and P = .02, respectively). In multivariable modeling, -DRB1 or -DPB1 mismatch and higher CD3+ graft cell dose were significantly associated with early
fever. Early
fever is more common after haplo compared with HLA-matched BMT.
Fever is associated with myeloablation, -DRB1 or -DPB1 mismatching, and higher CD3+ graft cell dose but not survival.